Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8<sup>+</sup> T cells and enhancing regulatory T cells.

Jevtovic, Andra; Pantic, Jelena; Jovanovic, Ivan; Milovanovic, Marija; Stanojevic, Ivan; Vojvodic, Danilo; Arsenijevic, Nebojsa; Lukic, Miodrag L; Radosavljevic, Gordana D

Interleukin-33 pretreatment promotes metastatic growth of murine melanoma by reducing the cytotoxic capacity of CD8⁺ T cells and enhancing regulatory T cells.

Jevtovic, Andra; Pantic, Jelena; Jovanovic, Ivan; Milovanovic, Marija; Stanojevic, Ivan; Vojvodic, Danilo; Arsenijevic, Nebojsa; Lukic, Miodrag L; Radosavljevic, Gordana D.

Afiliação

Jevtovic A; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia.
Pantic J; Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Jovanovic I; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia.
Milovanovic M; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia.
Stanojevic I; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia.
Vojvodic D; Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
Arsenijevic N; Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
Lukic ML; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia.
Radosavljevic GD; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000, Kragujevac, Serbia. miodrag.lukic@medf.kg.ac.rs.

Cancer Immunol Immunother ; 69(8): 1461-1475, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32285171

Assuntos

Linfócitos T CD8-Positivos/imunologia; Interleucina-33/administração & dosagem; Interleucina-33/sangue; Neoplasias Pulmonares/secundário; Melanoma Experimental/patologia; Linfócitos T Citotóxicos/imunologia; Linfócitos T Reguladores/imunologia; Animais; Apoptose; Biomarcadores Tumorais/sangue; Linfócitos T CD8-Positivos/efeitos dos fármacos; Estudos de Casos e Controles; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Humanos; Neoplasias Pulmonares/imunologia; Neoplasias Pulmonares/metabolismo; Melanoma Experimental/imunologia; Melanoma Experimental/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Prognóstico; Linfócitos T Citotóxicos/efeitos dos fármacos; Linfócitos T Reguladores/efeitos dos fármacos; Células Tumorais Cultivadas

Palavras-chave

CD8+ T cells; IL-33; Melanoma; Metastases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Linfócitos T Citotóxicos / Linfócitos T Reguladores / Linfócitos T CD8-Positivos / Interleucina-33 / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article

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