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Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog.
Leiva, Rosana; Gazzarrini, Sabrina; Esplugas, Roser; Moroni, Anna; Naesens, Lieve; Sureda, Francesc X; Vázquez, Santiago.
Afiliação
  • Leiva R; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona E-08028, Spain.
  • Gazzarrini S; Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan, Via Celoria 26, 20133 Milan, Italy.
  • Esplugas R; Unitat de Farmacologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, c./ St. Llorenç 21, Reus E-43201, Spain.
  • Moroni A; Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan, Via Celoria 26, 20133 Milan, Italy.
  • Naesens L; Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Sureda FX; Unitat de Farmacologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, c./ St. Llorenç 21, Reus E-43201, Spain.
  • Vázquez S; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona E-08028, Spain.
Tetrahedron Lett ; 56(10): 1272-1275, 2015 Mar 04.
Article em En | MEDLINE | ID: mdl-32287445
ABSTRACT
Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Tetrahedron Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Tetrahedron Lett Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha