Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog.
Tetrahedron Lett
; 56(10): 1272-1275, 2015 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-32287445
ABSTRACT
Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha