A-SLN, actarit loaded solid lipid nanoparticles; ACF-SLN, aceclofenac loaded solid lipid nanoparticles; AIA, antigen-induced arthritis; ALP, alkaline phosphate; ALT, alanine aminotransferase; AST, aspartate aminotransferase; C-SLN, curcumin loaded solid lipid nanoparticles; CEL-TS-LN, celecoxib loaded tristearin based lipidic nanoparticles; CFA, complete freund's adjuvant; CHNP, chitosan nanoparticle; CLSM, confocal laser scanning microscopy; COX- 1, cyclooxygenase - 1; COX- 2, cyclooxygenase - 2; DEX, dexamethasone; DEX-PMs, dexamethasone-loaded polymeric micelles; DMARD, disease modifying antirheumatic drugs; FA, folic acid; FR-ß, folate receptor-beta; GC, glucocorticoid; HA- AuNP/TCZ, hyaluronate gold nanoparticle/Tocilizumab; HEKcells, human embryonic kidney cells; HSA-NCs, human serum albumin nanocapsules; HUVEC, human umbilical vein cells; IL, interleukin; IND-NMs, indomethacin loaded polymeric micelles; Ig, immunoglobulin; Ind-NCs, indomethacin-loaded nanocapsules; Inflammation; LDE, lipidic nanoemulsion; LX-NMs, larnoxicam loaded nanomicelles; MTX-LCNCs, methotrexate-loaded lipidic core nanocapsules; NSAIDs, non steroidal anti-inflammatory drugs; Nanoformulation; Nanoparticles; P-SLN, piperine loaded solid lipid nanoparticle; PCL, polycaprolactone; PCL-PEG, poly (ethylene glycol)-block-poly (ε-caprolactone); PSA, polysialic acid; PSA-PCL-CyA-NMs, polysialic acid- polycaprolactone cyclosporine A nanomicelles; Pir-SLN, piroxicam solid lipid nanoparticles; RA, rheumatoid arthritis; RGD, arginine-glycine aspartic acid; RNAi, RNA interference; Rheumatoid arthritis; SLN, solid lipid nanoparticles; TAC-HSA-NPs, tacrolimus human serum albumin nanoparticle; TAC-LCNCs, tacrolimus loaded lipidic core nanocapsules; TNF-α, tumour necrosis factor; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; VIP, vasoactive intestinal peptide; mRNA, messenger RNA; shRNA, short hairpin RNA; siRNA, small interfering RNA