On Negative Heritability and Negative Estimates of Heritability.
Genetics
; 215(2): 343-357, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32291292
ABSTRACT
We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from misspecification of the standard additive mechanism that is supposed to justify the statistical procedure. Researchers should be open to the possibility that negative heritability estimates could reflect a real physical feature of the biological process from which the data were sampled.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenótipo
/
Variação Genética
/
Modelos Estatísticos
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Característica Quantitativa Herdável
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Herança Multifatorial
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Modelos Genéticos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Genetics
Ano de publicação:
2020
Tipo de documento:
Article