Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer.

Hsu, Ping-Ching; Kadlubar, Susan A; Siegel, Eric R; Rogers, Lora J; Todorova, Valentina K; Su, L Joseph; Makhoul, Issam

Hsu, Ping-Ching; Kadlubar, Susan A; Siegel, Eric R; Rogers, Lora J; Todorova, Valentina K; Su, L Joseph; Makhoul, Issam.

Afiliação

Hsu PC; Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Kadlubar SA; Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Siegel ER; Department of Biostatistics, Colleges of Medicine and of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Rogers LJ; Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Todorova VK; Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Su LJ; Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Makhoul I; Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

PLoS One ; 15(4): e0230248, 2020.

Article em En | MEDLINE | ID: mdl-32298288

RESUMO

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00203502.

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Neoplasias da Mama; Metilação de DNA/efeitos dos fármacos; DNA de Neoplasias/metabolismo; Terapia Neoadjuvante; Regiões Promotoras Genéticas; Adulto; Bevacizumab/administração & dosagem; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Ilhas de CpG; DNA (Citosina-5-)-Metiltransferases/metabolismo; Feminino; Humanos; Pessoa de Meia-Idade; Proteínas de Neoplasias/metabolismo; Fatores de Transcrição/metabolismo; DNA Metiltransferase 3B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / DNA de Neoplasias / Protocolos de Quimioterapia Combinada Antineoplásica / Regiões Promotoras Genéticas / Metilação de DNA / Terapia Neoadjuvante Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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