Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation.
Thorax
; 75(7): 600-605, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32303624
ABSTRACT
Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 exacerbated allergic airway inflammation, with increased bronchoalveolar lavage fluid cellularity, eosinophil numbers and total protein, and an increase in airway mucus production. Eosinophil apoptosis was suppressed by Mcl-1 overexpression, with this resistance to apoptosis attenuated by cyclin-dependent kinase inhibition which also rescued Mcl-1-exacerbated allergic airway inflammation. We propose that targeting Mcl-1 may be beneficial in treatment of allergic airway disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
RNA
/
Regulação da Expressão Gênica
/
Eosinófilos
/
Proteína de Sequência 1 de Leucemia de Células Mieloides
/
Hipersensibilidade
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Thorax
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido