Transposon mobilization in the human fungal pathogen <i>Cryptococcus</i> is mutagenic during infection and promotes drug resistance in vitro.

Gusa, Asiya; Williams, Jonathan D; Cho, Jang-Eun; Averette, Anna Floyd; Sun, Sheng; Shouse, Eva Mei; Heitman, Joseph; Alspaugh, J Andrew; Jinks-Robertson, Sue

Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro.

Gusa, Asiya; Williams, Jonathan D; Cho, Jang-Eun; Averette, Anna Floyd; Sun, Sheng; Shouse, Eva Mei; Heitman, Joseph; Alspaugh, J Andrew; Jinks-Robertson, Sue.

Afiliação

Gusa A; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Williams JD; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Cho JE; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Averette AF; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Sun S; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Shouse EM; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Heitman J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Alspaugh JA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Jinks-Robertson S; Department of Medicine, Duke University Medical Center, Durham, NC 27710.

Proc Natl Acad Sci U S A ; 117(18): 9973-9980, 2020 05 05.

Article em En | MEDLINE | ID: mdl-32303657

Assuntos

Antifúngicos/farmacologia; Cryptococcus neoformans/efeitos dos fármacos; Micoses/genética; Retroelementos/genética; Animais; Antifúngicos/efeitos adversos; Cryptococcus neoformans/patogenicidade; Farmacorresistência Fúngica/genética; Interações Hospedeiro-Patógeno/genética; Humanos; Camundongos; Mutagênese/genética; Micoses/microbiologia; Ácido Orótico/efeitos adversos; Ácido Orótico/análogos & derivados; Ácido Orótico/farmacologia; Sirolimo/farmacologia; Tacrolimo/farmacologia; Virulência/genética

Palavras-chave

Cryptococcus; drug resistance; fungal pathogen; temperature; transposons

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retroelementos / Cryptococcus neoformans / Micoses / Antifúngicos Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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