Detecting the Cognitive Prodrome of Dementia in Parkinson's Disease.
J Parkinsons Dis
; 10(3): 1033-1046, 2020.
Article
em En
| MEDLINE
| ID: mdl-32310188
ABSTRACT
BACKGROUND:
More than 75% of Parkinson's disease (PD) patients will develop dementia. Previous studies on the cognitive predictors of dementia in PD had some methodological limitations and the cognitive tests identified as good predictors vary greatly.OBJECTIVE:
This prospective cohort study aims to identify the optimal cognitive predictors of dementia in PD using complementary statistical methods.METHODS:
Eighty PD patients without dementia underwent polysomnographic recording, a neurological examination, and a complete neuropsychological assessment at baseline. They were then followed for a mean of 4.3 years. Baseline group comparisons and survival analyses were used to identify optimal cognitive predictors. Moreover, patients who developed dementia were pair-matched at baseline according to age, sex, and education to healthy controls (2ââ1), and receiver operating characteristic curves were calculated for cognitive tests.RESULTS:
At follow-up, 23 patients (29%) developed dementia. PD patients who developed dementia had poorer baseline performance and a higher proportion of clinically impaired performance on several cognitive tests. Impaired baseline performance on the Block Design subtest was the best independent predictor of dementia (HRâ=â8). Moreover, the Trail Making Test part B (time) and Verbal Fluency (semantic) had the best psychometric properties (area under the curve >0.90) for identifying PD patients at risk of dementia.CONCLUSION:
The present study identified three cognitive tests as the most accurate to detect individuals with PD at high risk of developing dementia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Demência
/
Disfunção Cognitiva
/
Sintomas Prodrômicos
/
Testes Neuropsicológicos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Parkinsons Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá