The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.

Wu, Yue; Wang, Xue; Xu, Feifei; Zhang, Lu; Wang, Tianjiao; Fu, Xueli; Jin, Tianzhi; Zhang, Weiying; Ye, Lihong

The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.

Wu, Yue; Wang, Xue; Xu, Feifei; Zhang, Lu; Wang, Tianjiao; Fu, Xueli; Jin, Tianzhi; Zhang, Weiying; Ye, Lihong.

Afiliação

Wu Y; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Wang X; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Xu F; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Zhang L; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Wang T; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Fu X; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Jin T; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Zhang W; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Ye L; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.

Nucleic Acids Res ; 48(9): 4858-4876, 2020 05 21.

Article em En | MEDLINE | ID: mdl-32313942

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago/metabolismo; Proteína HMGA2/metabolismo; Acetilação; Animais; Aspirina/farmacologia; Linhagem Celular Tumoral; DNA/metabolismo; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/mortalidade; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/genética; Carcinoma de Células Escamosas do Esôfago/mortalidade; Carcinoma de Células Escamosas do Esôfago/patologia; Feminino; Regulação Neoplásica da Expressão Gênica; Proteína HMGA2/química; Humanos; Lisina/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Nus; Prognóstico; Ligação Proteica; Estabilidade Proteica; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Ubiquitinação; Fatores de Transcrição de p300-CBP/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Proteína HMGA2 / Proteínas Adaptadoras de Transdução de Sinal / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article

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