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One new sesquiterpene pyridine alkaloid from the stems and leaves of Euonymus fortunei.
Kuang, Guang-Kai; Wang, Lin; Yang, Li-Li; Zhang, Yu-Bo; Luo, Ding; Zhou, Yi-Duo; Chen, Neng-Hua; Wu, Zhong-Nan; Wang, Guo-Cai; Li, Yao-Lan.
Afiliação
  • Kuang GK; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Wang L; Analytical and Testing Center, Jinan University, Guangzhou 510632, China.
  • Yang LL; Analytical and Testing Center, Jinan University, Guangzhou 510632, China.
  • Zhang YB; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Luo D; Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China.
  • Zhou YD; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Chen NH; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Wu ZN; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Wang GC; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Li YL; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
J Asian Nat Prod Res ; 23(4): 399-406, 2021 Apr.
Article em En | MEDLINE | ID: mdl-32319324
ABSTRACT
A new sesquiterpene pyridine alkaloid (1), along with four known compounds (2-5), were isolated from the stems and leaves of Euonymus fortunei. The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound 3 showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC50 value of 1.20 ± 0.10 µM than the positive control ribavirin with an IC50 value of 5.62 ± 0.49 µM.[Formula see text].
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Euonymus / Alcaloides Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Euonymus / Alcaloides Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China