An international cohort study of birth outcomes associated with hospitalized acute respiratory infection during pregnancy.
J Infect
; 81(1): 48-56, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32325131
ABSTRACT
OBJECTIVES:
Findings during the 2009 pandemic suggest severe maternal infection with pandemic influenza had adverse perinatal health consequences. Limited data exist evaluating the perinatal health effects of severe seasonal influenza and non-influenza infections during pregnancy.METHODS:
A retrospective cohort of pregnant women from Australia, Canada, Israel, and the United States was established using birth records to identify pregnancies and birth outcomes and hospital and laboratory testing records to identify influenza and non-influenza associated acute respiratory or febrile illness (ARFI) hospitalizations. ARFI hospitalized women were matched to non-hospitalized women (14) by country and season of conception. Log-binomial regression was used to estimate the relative risk (aRR) of preterm birth (PTB), small-for-gestational-age (SGA), and low birthweight (LBW) birth, adjusting for pre-existing medical conditions, maternal age, and parity.RESULTS:
950 pregnant women hospitalized with an ARFI were matched with 3,800 non-hospitalized pregnant women. Compared to non-hospitalized women, risk of PTB was greater among women hospitalized with influenza-associated ARFI (aRR 1.57; 95% CI 1.15-2.15) and non-influenza ARFI (aRR 2.78; 95% CI 2.12-3.65). Similar results were observed for LBW; there were no associations with SGA birth.CONCLUSIONS:
ARFI hospitalization during pregnancy was associated with increased risk of PTB and LBW.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nascimento Prematuro
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
País/Região como assunto:
Asia
/
Oceania
Idioma:
En
Revista:
J Infect
Ano de publicação:
2020
Tipo de documento:
Article