Early detection of left atrial and bi-ventricular myocardial strain abnormalities by MRI feature tracking in normotensive or hypertensive T2DM patients with preserved LV function.
BMC Cardiovasc Disord
; 20(1): 196, 2020 04 23.
Article
em En
| MEDLINE
| ID: mdl-32326882
ABSTRACT
BACKGROUND:
Previous studies have found that impaired global myocardial systolic strain is associated with cardiovascular events in T2DM patients. However, the effect of hypertension (HT) on left atrial (LA), right ventricular (RV) and left ventricular (LV) myocardial deformation in hypertensive T2DM patients has not been fully studied by cardiac magnetic resonance feature tracking (CMR-FT). Our aim was to assess LA, RV and LV strain in T2DM patients with T2DM-HT and without hypertension using CMR-FT and to determine the underlying relationships with clinical parameters.METHODS:
A total of 27 T2DM patients, 23 T2DM-HT patients and 31 controls were studied. LA, LV and RV strain was evaluated using CMR-FT. The clinical and biochemical parameters of the patients were collected.RESULTS:
The T2DM patients had reduced LA global circumferential strain (LAGCS), radial strain (LAGRS), longitudinal strain (LAGLS) and right ventricular longitudinal strain (RVGLS) compared with the controls (LAGCS 27.2 ± 2.1% vs 33.5 ± 2.4%; LAGRS - 28.6 ± 1.1% vs - 31.9 ± 1.3%; LAGLS 24.3 ± 1.3% vs 31.4 ± 1.5; RVGLS - 21.4 ± 1.2% vs - 26.3 ± 1.1%, p < 0.05 for all). The T2DM-HT patients had greater LAGCS, LAGRS and LAGLS than the T2DM patients (LAGCS 40.4 ± 3.8% vs 27.2 ± 2.1%; LAGRS - 36.8 ± 2.0% vs - 28.6 ± 1.1%; LAGLS 32.3 ± 2.4% vs 24.3 ± 1.3%, p < 0.05 for all). In the diabetic patients, LAGCS was associated with microalbuminuria levels (standardized ß = - 0.289, p = 0.021), and LAGCS, LAGRS and LAGLS were correlated with diuretic treatment (standardized ß =0.440, - 0.442, and 0.643, p < 0.05 for all).CONCLUSIONS:
CMR-FT may be considered a promising tool for the early detection of abnormal LA and RV myocardial strain. LA and RV strain values are impaired in T2DM patients. The amelioration of LA strain might be associated with hypertensive compensation or antihypertensive treatment, which requires to be confirmed in larger trials.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Função do Átrio Esquerdo
/
Função Ventricular Esquerda
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Função Ventricular Direita
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Disfunção Ventricular Direita
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Disfunção Ventricular Esquerda
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Imagem Cinética por Ressonância Magnética
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Diabetes Mellitus Tipo 2
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Cardiomiopatias Diabéticas
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Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMC Cardiovasc Disord
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China