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BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Brook, Byron; Harbeson, Danny J; Shannon, Casey P; Cai, Bing; He, Daniel; Ben-Othman, Rym; Francis, Freddy; Huang, Joe; Varankovich, Natallia; Liu, Aaron; Bao, Winnie; Bjerregaard-Andersen, Morten; Schaltz-Buchholzer, Frederik; Sanca, Lilica; Golding, Christian N; Larsen, Kristina Lindberg; Levy, Ofer; Kampmann, Beate; Tan, Rusung; Charles, Adrian; Wynn, James L; Shann, Frank; Aaby, Peter; Benn, Christine S; Tebbutt, Scott J; Kollmann, Tobias R; Amenyogbe, Nelly.
Afiliação
  • Brook B; Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  • Harbeson DJ; Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  • Shannon CP; PROOF Centre of Excellence, British Columbia, 10th floor, 1190 Hornby Street, Vancouver, BC V6Z 2K5, Canada.
  • Cai B; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
  • He D; Department of Pediatrics, University of British Columbia, and BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  • Ben-Othman R; Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  • Francis F; PROOF Centre of Excellence, British Columbia, 10th floor, 1190 Hornby Street, Vancouver, BC V6Z 2K5, Canada.
  • Huang J; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
  • Varankovich N; Department of Pediatrics, University of British Columbia, and BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  • Liu A; Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  • Bao W; Department of Pediatrics, University of British Columbia, and BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  • Bjerregaard-Andersen M; Department of Pediatrics, University of British Columbia, and BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  • Schaltz-Buchholzer F; Department of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC V5Z 1M9, Canada.
  • Sanca L; Department of Pediatrics, University of British Columbia, and BC Children's Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada.
  • Golding CN; Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  • Larsen KL; Research Center for Vitamins and Vaccines (CVIVA), Statens Serum Institut (SSI), Artillerivej 5, 2300 Copenhagen S, Denmark.
  • Levy O; Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark.
  • Kampmann B; Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  • Tan R; OPEN, Institute of Clinical Research and Danish Institute for Advanced Science, University of Southern Denmark, and Odense University Hospital, J.B. Winsløws Vej, 5000 Odense C, Denmark.
  • Charles A; Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  • Wynn JL; Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  • Shann F; Research Center for Vitamins and Vaccines (CVIVA), Statens Serum Institut (SSI), Artillerivej 5, 2300 Copenhagen S, Denmark.
  • Aaby P; Bandim Health Project, Indepth Network, Apartado 861, 1004 Bissau, Guinea-Bissau.
  • Benn CS; Research Center for Vitamins and Vaccines (CVIVA), Statens Serum Institut (SSI), Artillerivej 5, 2300 Copenhagen S, Denmark.
  • Tebbutt SJ; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.
  • Kollmann TR; Harvard Medical School, Boston, MA 02115, USA.
  • Amenyogbe N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sci Transl Med ; 12(542)2020 05 06.
Article em En | MEDLINE | ID: mdl-32376769
ABSTRACT
Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration. This was necessary and sufficient to drive emergency granulopoiesis (EG), resulting in a marked increase in neutrophils. This increase in neutrophils was directly and quantitatively responsible for protection from sepsis. Rapid induction of EG after BCG administration also occurred in three independent cohorts of human neonates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Sepse Neonatal Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Sepse Neonatal Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá