Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis.
Lab Med
; 51(6): 614-619, 2020 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-32382753
ABSTRACT
OBJECTIVE:
To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis.METHODS:
Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined.RESULTS:
Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P < .01) and peaked at 48 h. PCT and CRP levels were similar in the patients at admission but increased by 5 times to 10 times in the next 48 h, especially in the patients with septic shock. WBC levels remained high and did not change dramatically. Receiver operating characteristic analysis revealed that the area under the curve, sensitivity, and specificity values of sCD14-ST to diagnose sepsis were much higher than those of the other markers.CONCLUSION:
Compared with PCT, CRP, and WBC, sCD14-ST is a better biomarker for the early diagnosis of sepsis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Sepse
/
Receptores de Lipopolissacarídeos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Lab Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China