Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis.

Yoon, Ha Young; Ahn, Min Hyoung; Yee, Jeong; Lee, Nari; Han, Ji Min; Gwak, Hye Sun

Yoon, Ha Young; Ahn, Min Hyoung; Yee, Jeong; Lee, Nari; Han, Ji Min; Gwak, Hye Sun.

Afiliação

Yoon HY; Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
Ahn MH; College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
Yee J; Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
Lee N; Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
Han JM; Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
Gwak HS; Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea. hsgwak@ewha.ac.kr.

Eur J Clin Pharmacol ; 76(8): 1053-1058, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32385545

Assuntos

Anticonvulsivantes/sangue; Citocromo P-450 CYP2A6/genética; Citocromo P-450 CYP2C9/genética; Epilepsia/sangue; Epilepsia/genética; Ácido Valproico/sangue; Anticonvulsivantes/farmacocinética; Anticonvulsivantes/uso terapêutico; Epilepsia/tratamento farmacológico; Humanos; Ácido Valproico/farmacocinética; Ácido Valproico/uso terapêutico

Palavras-chave

CYP2A6*4; CYP2C9*3; Epilepsy; Meta-analysis; Plasma concentration; Valproic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Valproico / Epilepsia / Citocromo P-450 CYP2A6 / Citocromo P-450 CYP2C9 / Anticonvulsivantes Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2020 Tipo de documento: Article

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