Targeting Arousal and Sleep through Noninvasive Brain Stimulation to Improve Mental Health.
Neuropsychobiology
; 79(4-5): 284-292, 2020.
Article
em En
| MEDLINE
| ID: mdl-32408296
ABSTRACT
Arousal and sleep represent fundamental physiological domains, and alterations in the form of insomnia (difficulty falling or staying asleep) or hypersomnia (increased propensity for falling asleep or increased sleep duration) are prevalent clinical problems. Current first-line treatments include psychotherapy and pharmacotherapy. Despite significant success, a number of patients do not benefit sufficiently. Progress is limited by an incomplete understanding of the -neurobiology of insomnia and hypersomnia. This work summarizes current concepts of the regulation of arousal and sleep and its modulation through noninvasive brain stimulation (NIBS), including transcranial magnetic, current, and auditory stimulation. Particularly, we suggest (1) characterization of patients with sleep problems - across diagnostic entities of mental disorders - based on specific alterations of sleep, including alterations of sleep slow waves, sleep spindles, cross-frequency coupling of brain oscillations, local sleep-wake regulation, and REM sleep and (2) targeting these with specific NIBS techniques. While evidence is accumulating that the modulation of specific alterations of sleep through NIBS is feasible, it remains to be tested whether this translates to clinically relevant effects and new treatment developments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
/
Fases do Sono
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Estimulação Acústica
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Estimulação Magnética Transcraniana
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Estimulação Transcraniana por Corrente Contínua
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Distúrbios do Sono por Sonolência Excessiva
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Distúrbios do Início e da Manutenção do Sono
Limite:
Humans
Idioma:
En
Revista:
Neuropsychobiology
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suíça