[Reactogenicity and immunologic activity of live enteric Sonne dysentery vaccine from a spontaneous mutant]. / Reaktogennost' i immunologicheskaia aktivnost' zhivoi énteral'noi dizenteriinoi vaktsiny zonne iz spontannogo mutanta
Zh Mikrobiol Epidemiol Immunobiol
; (2): 111-7, 1977 Feb.
Article
em Ru
| MEDLINE
| ID: mdl-324177
ABSTRACT
Live dysentery Sonne vaccine from a spontaneous mutant proved to be practically areactogenic and specifically harmless in oral immunization of children aged from 7 to 13 years, in doses of from 3 to 25 milliard live microbial cells and in single and triple immunization schemes. Weak reactions of the gastro-intestinal tract were noted with the same frequency (1.7%) in children immunized with the vaccine and in children given placebo (2.2%). There proved to be a significant increase in the serum of the immunized persons of the level of specific hemagglutinins, and also of the IgA-and IgM-titers in 82% of the persons vaccinated; they persisted at a high level for 2 months. The appearance of IgA-antibodies in high titres in the persons vaccinated orally pointed to a marked local and general immunological activity of the live dysentery Sonne vaccine from the spontaneous mutant processing the capacity to survive in the intestine of children for a long time.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Vacinação
/
Disenteria Bacilar
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Humans
País/Região como assunto:
Europa
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Ano de publicação:
1977
Tipo de documento:
Article