Asiaticoside attenuates bleomycin-induced pulmonary fibrosis in A2aR<sup>-/-</sup> mice by promoting the BMP7/Smad1/5 signaling pathway.

Zhang, Ting; Dai, Jianyi; Ye, Wenjing; Cai, Luqiong; Wei, Jinqiu; Chen, Mayun; Huang, Xiaoying; Wang, Xiaobing

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis in A2aR^-/- mice by promoting the BMP7/Smad1/5 signaling pathway.

Zhang, Ting; Dai, Jianyi; Ye, Wenjing; Cai, Luqiong; Wei, Jinqiu; Chen, Mayun; Huang, Xiaoying; Wang, Xiaobing.

Afiliação

Zhang T; Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Wenling, Zhejiang, China.
Dai J; Department of Cardiology, The People's Hospital of Yuhuan, Zhejiang, China.
Ye W; Division of Rheumatology and Immunology, Huashan Hospital, Fudan University, Shanghai, China.
Cai L; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Wei J; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Chen M; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Huang X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: zjwzhxy@126.com.
Wang X; Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: gale820907@163.com.

Biochem Biophys Res Commun ; 527(3): 662-667, 2020 06 30.

Article em En | MEDLINE | ID: mdl-32423816

Assuntos

Proteína Morfogenética Óssea 7/metabolismo; Fibrose Pulmonar/tratamento farmacológico; Receptor A2A de Adenosina/genética; Transdução de Sinais/efeitos dos fármacos; Proteínas Smad/metabolismo; Triterpenos/uso terapêutico; Animais; Bleomicina; Centella/química; Deleção de Genes; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/genética; Fibrose Pulmonar/metabolismo; Triterpenos/química

Palavras-chave

Adenosine 2A receptor; Asiaticoside; Bleomycin; Bone morphogenetic protein 7; Pulmonary fibrosis; Smad1/5

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Triterpenos / Transdução de Sinais / Receptor A2A de Adenosina / Proteínas Smad / Proteína Morfogenética Óssea 7 Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google