Systemic Regulation of Local Cell Competition.

Hirabayashi, Susumu; Cagan, Ross

Hirabayashi, Susumu; Cagan, Ross.

Afiliação

Hirabayashi S; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Cagan R; Institute of Cancer Sciences-University of Glasgow, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden, Glasgow, Scotland G61 1BD, UK. Electronic address: ross.cagan@glasgow.ac.uk.

Dev Cell ; 53(4): 371-372, 2020 05 18.

Article em En | MEDLINE | ID: mdl-32428451

ABSTRACT

ABSTRACT

Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes tumorigenesis by abrogating local cell competition.

Assuntos

Proteínas de Drosophila; Hiperinsulinismo; Animais; Competição entre as Células; Proliferação de Células; Transformação Celular Neoplásica; Proteínas de Drosophila/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila / Hiperinsulinismo Limite: Animals Idioma: En Revista: Dev Cell Assunto da revista: EMBRIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

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