Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function.

Seacrist, Corey D; Kuenze, Georg; Hoffmann, Reece M; Moeller, Brandon E; Burke, John E; Meiler, Jens; Blind, Raymond D

Seacrist, Corey D; Kuenze, Georg; Hoffmann, Reece M; Moeller, Brandon E; Burke, John E; Meiler, Jens; Blind, Raymond D.

Afiliação

Seacrist CD; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Kuenze G; Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Hoffmann RM; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Moeller BE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Meiler J; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Institute for Drug Discovery, Leipzig University, Leipzig, Germany; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA. Electronic address:
Blind RD; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Division of Diabetes Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA; Center for Structural Bio

Structure ; 28(7): 830-846.e9, 2020 07 07.

Article em En | MEDLINE | ID: mdl-32433991

Assuntos

Simulação de Dinâmica Molecular; Receptores Citoplasmáticos e Nucleares/química; Sítios de Ligação; DNA/química; DNA/metabolismo; Células HEK293; Humanos; Simulação de Acoplamento Molecular; Ligação Proteica; Receptores Citoplasmáticos e Nucleares/metabolismo

Palavras-chave

BS3; Dax1 Dax-1 Nr0b1; benzophenone artificial amino acid; disulfide crosslink mass spectrometry; hydrogen-deuterium exchange mass spectrometry; integrated structural modeling; nuclear lipids; nuclear phospholipid signaling; nuclear receptor lipidomics; small-angle X-ray scattering; ß-catenin CTNNB1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Citoplasmáticos e Nucleares / Simulação de Dinâmica Molecular Limite: Humans Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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