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Lenvatinib suppresses cancer stem-like cells in HCC by inhibiting FGFR1-3 signaling, but not FGFR4 signaling.
Shigesawa, Taku; Maehara, Osamu; Suda, Goki; Natsuizaka, Mitsuteru; Kimura, Megumi; Shimazaki, Tomoe; Yamamoto, Koji; Yamada, Ren; Kitagataya, Takashi; Nakamura, Akihisa; Suzuki, Kazuharu; Ohara, Masatsugu; Kawagishi, Naoki; Umemura, Machiko; Nakai, Masato; Sho, Takuya; Morikawa, Kenichi; Ogawa, Koji; Ohnishi, Shunsuke; Sugiyama, Masaya; Mizokami, Masashi; Takeda, Hiroshi; Sakamoto, Naoya.
Afiliação
  • Shigesawa T; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Maehara O; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Suda G; Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences Hokkaido University, Sapporo, Japan.
  • Natsuizaka M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Kimura M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Shimazaki T; Department of Internal Medicine, Natsuizaka Clinic, Sapporo, Japan.
  • Yamamoto K; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Yamada R; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Kitagataya T; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Nakamura A; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Suzuki K; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Ohara M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Kawagishi N; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Umemura M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Nakai M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Sho T; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Morikawa K; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Ogawa K; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Ohnishi S; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Sugiyama M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Mizokami M; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Takeda H; Genome Medical Sciences Project, National Center for Global Health Medicine, Tokyo, Japan.
  • Sakamoto N; Genome Medical Sciences Project, National Center for Global Health Medicine, Tokyo, Japan.
Carcinogenesis ; 42(1): 58-69, 2021 02 11.
Article em En | MEDLINE | ID: mdl-32449510
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Quinolinas / Células-Tronco Neoplásicas / Carcinoma Hepatocelular / Inibidores de Proteínas Quinases / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Carcinogenesis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Quinolinas / Células-Tronco Neoplásicas / Carcinoma Hepatocelular / Inibidores de Proteínas Quinases / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Carcinogenesis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão