Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate.
Arch Toxicol
; 94(6): 2249-2254, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32451600
ABSTRACT
Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill causation criteria to VEA and the EVALI outbreak to clarify what further areas of study are needed to strengthen the causal argument. Additionally, we highlight the need for systematized approaches to rapidly identify the cause of mass poisoning events of unknown etiology.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Sistemas Eletrônicos de Liberação de Nicotina
/
Vaping
/
Vapor do Cigarro Eletrônico
/
Pneumopatias
/
Acetatos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Arch Toxicol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos