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A three-lncRNA signature predicts clinical outcomes in low-grade glioma patients after radiotherapy.
Lin, Wanzun; Huang, Zongwei; Xu, Yanyan; Chen, Xiaochuan; Chen, Ting; Ye, Yuling; Ding, Jianming; Chen, Zhangjie; Chen, Long; Qiu, Xianxin; Qiu, Sufang.
Afiliação
  • Lin W; Department of Radiation Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.
  • Huang Z; Department of Radiation Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, China.
  • Xu Y; Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Chen X; Department of Radiation Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, China.
  • Chen T; Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Ye Y; Department of Radiation Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, China.
  • Ding J; Department of Radiation Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.
  • Chen Z; Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Chen L; Division of Neurocritical Care, Huashan Hospital, Fudan University, Shanghai, China.
  • Qiu X; Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
  • Qiu S; Department of Radiation Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, China.
Aging (Albany NY) ; 12(10): 9188-9204, 2020 05 26.
Article em En | MEDLINE | ID: mdl-32453707
ABSTRACT
Although radiation therapy (RT) plays a critical role in the treatment of low-grade glioma (LGG), many patients suffer from adverse effects without experiencing survival benefits. In various carcinomas, long non-coding RNAs (lncRNAs) contribute to pathogenic processes, including tumorigenesis, metastasis, chemoresistance, and radioresistance. Currently, the role of lncRNAs in the radiosensitivity of LGG is largely unknown. Here, we downloaded clinical data for 167 LGG patients from The Cancer Genome Atlas database and divided them between radiosensitive and radioresistant groups based on their clinical outcomes after receiving radiotherapy. We identified 37 lncRNAs that were differentially expressed (DElncRNAs) between the groups. Functional enrichment analysis revealed that their potential target mRNAs were mainly enriched in the PI3K-Akt and MAPK signaling pathways and in DNA damage response. Kaplan-Meier survival analysis revealed that increased expression of six lncRNAs was significantly associated with radiosensitivity. We then developed a risk signature based on three of the DElncRNAs that served as an independent biomarker for predicting LGG patient outcomes after radiotherapy. In vitro experiments further validated the biological function of these lncRNAs on low-grade glioma radiation response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Transcriptoma / RNA Longo não Codificante / Glioma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Transcriptoma / RNA Longo não Codificante / Glioma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China