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Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development.
Pegoretti, Valentina; Swanson, Kathryn A; Bethea, John R; Probert, Lesley; Eisel, Ulrich L M; Fischer, Roman.
Afiliação
  • Pegoretti V; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9747 AG Groningen, Netherlands.
  • Swanson KA; Department of Biology, Drexel University, Philadelphia, PA 19104, USA.
  • Bethea JR; Department of Biology, Drexel University, Philadelphia, PA 19104, USA.
  • Probert L; Laboratory of Molecular Genetics, Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Eisel ULM; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9747 AG Groningen, Netherlands.
  • Fischer R; Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.
Oxid Med Cell Longev ; 2020: 7191080, 2020.
Article em En | MEDLINE | ID: mdl-32454942
CNS inflammation is a major driver of MS pathology. Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression. Next to these immune-mediated mechanisms, other mediators contribute to MS pathology. These include immune-independent cell death of oligodendrocytes and neurons as well as oxidative stress-induced tissue damage. In particular, the complex influence of oxidative stress on inflammation and vice versa makes therapeutic interference complex. All approved MS therapeutics work by modulating the autoimmune response. However, despite substantial developments in the treatment of the relapsing-remitting form of MS, approved therapies for the progressive forms of MS as well as for MS-associated concomitants are limited and much needed. Here, we summarize the contribution of inflammation and oxidative stress to MS pathology and discuss consequences for MS therapy development.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Inflamação / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Inflamação / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda