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COVID-19 in solid organ transplant recipients: a single-center experience.
Hoek, Rogier A S; Manintveld, Olivier C; Betjes, Michiel G H; Hellemons, Merel E; Seghers, Leonard; Van Kampen, Jeroen A A; Caliskan, Kadir; van de Wetering, Jacqueline; van den Hoogen, Martijn; Metselaar, Herold J; Hesselink, Dennis A.
Afiliação
  • Hoek RAS; Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Manintveld OC; Department of Cardiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Betjes MGH; Department of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Hellemons ME; Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Seghers L; Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Van Kampen JAA; Department of Viroscience, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Caliskan K; Department of Cardiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • van de Wetering J; Department of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • van den Hoogen M; Department of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Metselaar HJ; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Hesselink DA; Department of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Transpl Int ; 33(9): 1099-1105, 2020 09.
Article em En | MEDLINE | ID: mdl-32460390
Solid organ transplant (SOT) recipients may be at risk for severe COVID-19. Data on the clinical course of COVID-19 in immunosuppressed patients are limited, and the effective treatment strategy for these patients is unknown. We describe our institutional experience with COVID-19 in SOT. Demographic, clinical, and treatment data were extracted from the electronic patient files. A total of 23 SOT transplant recipients suffering from COVID-19 were identified (n = 3 heart; n = 15 kidney; n = 1 kidney-after-heart; n = 3 lung, and n = 1 liver transplant recipient). The presenting symptoms were similar to nonimmunocompromised patients. Eighty-three percent (19/23) of the patients required hospitalization, but only two of these were transferred to the intensive care unit. Five patients died from COVID-19; all had high Clinical Frailty Scores. In four of these patients, mechanical ventilation was deemed futile. In 57% of patients, the immunosuppressive therapy was not changed and only three patients were treated with chloroquine. Most patients recovered without experimental antiviral therapy. Modification of the immunosuppressive regimen alone could be a therapeutic option for SOT recipients suffering from moderate to severe COVID-19. Pre-existent frailty is associated with death from COVID-19.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Órgãos / Terapia de Imunossupressão / Transplantados / COVID-19 Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Órgãos / Terapia de Imunossupressão / Transplantados / COVID-19 Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda