Your browser doesn't support javascript.
loading
The decline of FANCM immunohistochemical expression in prostate cancer stroma correlates with the grade group.
Dzaparidze, Georgi; Anion, Evelin; Laan, Maris; Minajeva, Ave.
Afiliação
  • Dzaparidze G; East Tallinn Central Hospital, Tallinn, Estonia.
  • Anion E; East Tallinn Central Hospital, Tallinn, Estonia.
  • Laan M; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
  • Minajeva A; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Pathol Int ; 70(8): 542-550, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32462745
Prostate adenocarcinoma (PCa) stromal markers have recently gained attention as complementary diagnostic tools. The DNA reparation complex protein FANCM has been shown to express in the normal prostate stroma and FANCM gene alterations to be associated with PCa susceptibility; this has led to the hypothesis that an insufficient level of FANCM expression may provide additional information for the evaluation of PCa. The study cohort comprised 60 radical prostatectomy specimens. The controls involved 11 autopsies (CTRL) and non-cancerous tissue (NCT) areas from the prostatectomy specimen. The samples were stained with the FANCM antibody. The quantification of the stromal staining index (SSI) was made using ImageJ and QuPath. Overall, 655 regions of interest (ROI) were analyzed. FANCM expression appeared equally intense and stroma specific in both CTRL and NCT, indicating the absence of underlying baseline alterations. Within the age span of the cohort 47-89 years, no significant effect of the age of the patients on the FANCM expression was seen. FANCM demonstrated Gleason grade (G) dependent decline in PCa, being statistically significant in controls versus G1 and G2 versus G3. In other adjacent International Society of Urological Pathology (ISUP) groups, it remained insignificant, still being meaningful between high and low-grade cancers.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / DNA Helicases / Gradação de Tumores Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Pathol Int Assunto da revista: PATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estônia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / DNA Helicases / Gradação de Tumores Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Pathol Int Assunto da revista: PATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estônia