Performance of ultrasonography screening for breast cancer: a systematic review and meta-analysis.
BMC Cancer
; 20(1): 499, 2020 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-32487106
ABSTRACT
BACKGROUND:
To investigate the performance of primary ultrasound (P-US) screening for breast cancer, and that of supplemental ultrasound (S-US) screening for breast cancer after negative mammography (MAM).METHODS:
Electronic databases (PubMed, Scopus, Web of Science, and Embase) were systematically searched to identify relevant studies published between January 2003 and May 2018. Only high-quality or fair-quality studies reporting any of the following performance values for P-US or S-US screening were included sensitivity, specificity, cancer detected rate (CDR), recall rate (RR), biopsy rate (BR), proportion of invasive cancers among screening-detected cancers (ProIC), and proportion of node-negative cancers among screening-detected invasive cancers (ProNNIC).RESULTS:
Twenty-three studies were included, including 12 studies in which S-US screening was used after negative MAM and 11 joint screening studies in which both primary MAM (P-MAM) and P-US were used. Meta-analyses revealed that S-US screening could detect 96% [95% confidential intervals (CIs) 82 to 99%] of occult breast cancers missed by MAM and identify 93% (95% CIs 89 to 96%) of healthy women, with a CDR of 3.0/1000 (95% CIs 1.8/1000 to 4.6/1000), RR of 8.8% (95% CIs 5.0 to 13.4%), BR of 3.9% (95% CIs 2.7 to 5.4%), ProIC of 73.9% (95% CIs 49.0 to 93.7%), and ProNNIC of 70.9% (95% CIs 46.0 to 91.6%). Compared with P-MAM screening, P-US screening led to the recall of significantly more women with positive screening results [1.5% (95% CIs0.6 to 2.3%), P = 0.001] and detected significantly more invasive cancers [16.3% (95% CIs 10.6 to 22.1%), P < 0.001]. However, there were no significant differences for other performance measures between the two screening methods, including sensitivity, specificity, CDR, BR, and ProNNIC.CONCLUSIONS:
Current evidence suggests that S-US screening could detect occult breast cancers missed by MAM. P-US screening has shown to be comparable to P-MAM screening in women with dense breasts in terms of sensitivity, specificity, cancer detection rate, and biopsy rate, but with higher recall rates and higher detection rates for invasive cancers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Programas de Rastreamento
/
Ultrassonografia Mamária
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Detecção Precoce de Câncer
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
/
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
BMC Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China