Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Cao, Yue; Cao, Wangjia; Qiu, Yangmin; Zhou, Yuxin; Guo, Qinglong; Gao, Yuan; Lu, Na

Cao, Yue; Cao, Wangjia; Qiu, Yangmin; Zhou, Yuxin; Guo, Qinglong; Gao, Yuan; Lu, Na.

Afiliação

Cao Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
Cao W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
Qiu Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
Zhou Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
Guo Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China.
Gao Y; Pharmaceutical Animal Experimental Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address: cpugaoyuan@163.com.
Lu N; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address: nalu@cpu.edu.cn.

Pharmacol Res ; 159: 104981, 2020 09.

Article em En | MEDLINE | ID: mdl-32492489

Assuntos

Actinina/metabolismo; Antineoplásicos Fitogênicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Fibroblastos Associados a Câncer/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Flavonoides/farmacologia; Actinina/genética; Animais; Antineoplásicos Fitogênicos/metabolismo; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Fibroblastos Associados a Câncer/metabolismo; Fibroblastos Associados a Câncer/patologia; Linhagem Celular Tumoral; Regulação para Baixo; Feminino; Flavonoides/metabolismo; Regulação Neoplásica da Expressão Gênica; Camundongos Endogâmicos BALB C; Camundongos Nus; Camundongos Transgênicos; Metástase Neoplásica; Fenótipo; Ligação Proteica; Transdução de Sinais; Microambiente Tumoral

Palavras-chave

ACTN1; CAFs; Cancer metastasis; OA; Oroxylin A (CID: 5320315); STAT3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Actinina / Neoplasias da Mama / Movimento Celular / Fibroblastos Associados a Câncer / Antineoplásicos Fitogênicos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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