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Histopathologic Influences of Comorbid Smoking Status in Chronic Rhinosinusitis.
Kuhar, Hannah N; Ganti, Ashwin; Brown, Hannah J; Gattuso, Paolo; Ghai, Ritu; Mahdavinia, Mahboobeh; Batra, Pete S; Tajudeen, Bobby A.
Afiliação
  • Kuhar HN; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
  • Ganti A; Rush Medical College, Chicago, Illinois.
  • Brown HJ; Rush Medical College, Chicago, Illinois.
  • Gattuso P; Department of Pathology, Rush University Medical Center, Chicago, Illinois.
  • Ghai R; Department of Pathology, Rush University Medical Center, Chicago, Illinois.
  • Mahdavinia M; Department of Immunology and Microbiology, Allergy/Immunology Section, Rush University Medical Center, Chicago, Illinois.
  • Batra PS; Rhinology and Skull Base Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois.
  • Tajudeen BA; Rhinology and Skull Base Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois.
Am J Rhinol Allergy ; 34(6): 775-783, 2020 Nov.
Article em En | MEDLINE | ID: mdl-32498540
BACKGROUND: Smoking status has been established as a known irritant of the upper and lower respiratory tracts, leading to inflammation throughout the respiratory system. Tobacco smoking is one comorbidity encountered among chronic rhinosinusitis (CRS) patients. The histopathologic features of CRS and comorbid smoking status have yet to be determined by structured histopathology and may have important implications on disease management. METHODS: Retrospective study of structured histopathology reports analyzing sinus tissue removed during functional endoscopic sinus surgery. Histopathology variables were compared among patients with CRS who were reported as never smokers, former smokers, or current smokers. RESULTS: A total of 285 CRS patients were included: 173 never smokers, 85 former smokers, and 27 current smokers. When compared with former smokers, current smokers demonstrated increased basement membrane thickening (88.9% vs 67.1%, P <.020). Compared with never smokers, former and current smokers collectively demonstrated increased hyperplastic changes (14.3% vs 6.9%, P < .035), increased squamous metaplasia (26.8% vs 17.3%, P < .040), and trends toward increased basement membrane thickening (72.3% vs 65.3%, P < .124) and increased fibrosis (47.3% vs 40.5%, P < .154). CONCLUSION: Smoking status may influence histopathologic tissue-level changes in CRS disease. Interestingly, former and current smokers maintained few differences in histopathology. However, former and current smokers collectively demonstrated increased chronic inflammatory changes compared with never smokers. These findings suggest that the timing of smoking exposure has limited effect on the tissue level, rather exposure overall influences inflammatory change. These findings may have important implications on medical and surgical management of CRS disease and comorbid smoking status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seios Paranasais / Sinusite / Rinite Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Am J Rhinol Allergy Assunto da revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seios Paranasais / Sinusite / Rinite Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Am J Rhinol Allergy Assunto da revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article