Piribedil loaded thermo-responsive nasal in situ gelling system for enhanced delivery to the brain: formulation optimization, physical characterization, and in vitro and in vivo evaluation.

Uppuluri, Chandra Teja; Ravi, Punna Rao; Dalvi, Avantika V; Shaikh, Shafik Shakil; Kale, Suvarna R

Uppuluri, Chandra Teja; Ravi, Punna Rao; Dalvi, Avantika V; Shaikh, Shafik Shakil; Kale, Suvarna R.

Afiliação

Uppuluri CT; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar (Village), Kapra (M), Hyderabad, Telangana, 500078, India.
Ravi PR; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar (Village), Kapra (M), Hyderabad, Telangana, 500078, India. rpunnarao@hyderabad.bits-pilani.ac.in.
Dalvi AV; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar (Village), Kapra (M), Hyderabad, Telangana, 500078, India.
Shaikh SS; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar (Village), Kapra (M), Hyderabad, Telangana, 500078, India.
Kale SR; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Jawaharnagar (Village), Kapra (M), Hyderabad, Telangana, 500078, India.

Drug Deliv Transl Res ; 11(3): 909-926, 2021 06.

Article em En | MEDLINE | ID: mdl-32514705

Assuntos

Mucosa Nasal; Piribedil; Administração Intranasal; Animais; Disponibilidade Biológica; Encéfalo; Sistemas de Liberação de Medicamentos; Géis; Mucosa Nasal/metabolismo; Piribedil/metabolismo; Piribedil/farmacologia; Ratos; Ratos Wistar

Palavras-chave

Brain uptake; Intranasal administration; Methyl cellulose in situ gels; Piribedil; Rheological evaluation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piribedil / Mucosa Nasal Limite: Animals Idioma: En Revista: Drug Deliv Transl Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

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