Peroxisome proliferator-activated receptor gamma-ligand-binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration.

Shoaito, Hussein; Chauveau, Sabine; Gosseaume, Camille; Bourguet, William; Vigouroux, Corinne; Vatier, Camille; Pienkowski, Catherine; Fournier, Thierry; Degrelle, Séverine A

Shoaito, Hussein; Chauveau, Sabine; Gosseaume, Camille; Bourguet, William; Vigouroux, Corinne; Vatier, Camille; Pienkowski, Catherine; Fournier, Thierry; Degrelle, Séverine A.

Afiliação

Shoaito H; INSERM, UMR-S1139 (3PHM), Université de Paris, Paris, France.
Chauveau S; INSERM, UMR-S1139 (3PHM), Université de Paris, Paris, France.
Gosseaume C; Laboratoire ICARE, Biopôle Clermont-Limagne, Saint-Beauzire, France.
Bourguet W; Inserm UMR-S938, Department of Endocrinology, Diabetology and Reproductive Endocrinology, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Saint-Antoine Hospital, National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS)
Vigouroux C; INSERM, CNRS, Centre de Biochimie Structurale (CBS), Université de Montpellier, Montpellier, France.
Vatier C; Inserm UMR-S938, Department of Endocrinology, Diabetology and Reproductive Endocrinology, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Saint-Antoine Hospital, National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS)
Pienkowski C; Department of Molecular Biology and Genetics, AP-HP, Saint-Antoine Hospital, Paris, France.
Fournier T; Inserm UMR-S938, Department of Endocrinology, Diabetology and Reproductive Endocrinology, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Saint-Antoine Hospital, National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS)
Degrelle SA; Endocrinology Unit, Reference Centre for Rare Gynecologic Diseases, Toulouse, France.

J Cell Mol Med ; 24(13): 7660-7669, 2020 07.

Article em En | MEDLINE | ID: mdl-32519441

Assuntos

Movimento Celular; Fibroblastos/patologia; Lipodistrofia Parcial Familiar/genética; Mutação/genética; PPAR gama/química; PPAR gama/genética; Trofoblastos/patologia; Animais; Fusão Celular; Fibroblastos/metabolismo; Humanos; Ligantes; Lipodistrofia Parcial Familiar/patologia; Camundongos; Modelos Moleculares; Células NIH 3T3; PPAR gama/metabolismo; Domínios Proteicos; Trofoblastos/metabolismo

Palavras-chave

PPARG; Placenta; cell fusion; cell migration; familial partial lipodystrophy type 3 (FPLD3); trophoblast differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trofoblastos / Movimento Celular / PPAR gama / Lipodistrofia Parcial Familiar / Fibroblastos / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França

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