Aging and Positive Mood: Longitudinal Neurobiological and Cognitive Correlates.
Am J Geriatr Psychiatry
; 28(9): 946-956, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32527600
ABSTRACT
OBJECTIVE:
Despite the losses commonly associated with aging, older adults seem to possess particularly preserved emotional regulation. To further understand this phenomenon, the authors examined longitudinal trajectories between age, depressive symptoms, brain structure, and cognition.METHODS:
Seven hundred and sixteen functionally intact older adults (age Mâ¯=â¯67.9, 56.8% female), followed longitudinally (visit range 1-13, Mâ¯=â¯2.5), completed cognitive testing and the Geriatric Depression Scale (GDS). A subset (Nâ¯=â¯327) underwent 3T brain MRI. Mixed-effects linear regression models were conducted controlling for sex, education, and total intracranial volume.RESULTS:
There was a significant interaction between age and time on GDS, such that GDS improved with increasing age over time, but attenuated around age 71 (age*time bâ¯=â¯0.10, p <0.001). Fractional anisotropy (FA) and mean diffusivity interacted with age to predict longitudinal changes in GDS (FA bâ¯=â¯-0.02, pâ¯=â¯0.01; MD bâ¯=â¯0.03, pâ¯=â¯0.007), such that age-related benefits on GDS were attenuated in those with declining FA. Executive function (EF) and processing speed also interacted with age to predict longitudinal changes in GDS (EF bâ¯=â¯-0.04, pâ¯=â¯0.03; speed bâ¯=â¯0.04, pâ¯=â¯0.04). Again, the positive effect of age on GDS attenuated in those with worsening EF and speed. There were no associations with memory, semantic fluency, or gray matter (p values >0.05).CONCLUSION:
EF, processing speed, and white matter integrity moderated the longitudinal relationship between age and mood. Previous studies demonstrate the link between positivity and better cognitive control, leading to improved mood in older adults. Our results are not only consistent, but establish a potential neurobiological correlate. Future research further exploring biological mechanisms driving psychological processes may have important therapeutic implications.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Envelhecimento
/
Cognição
/
Depressão
/
Otimismo
/
Regulação Emocional
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá