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Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System.
Kim, Dong-Hoon; Son, Byoung Kwan; Min, Kyueng-Whan; Han, Sang Kuk; Na, Ji Ung; Choi, Pil Cho; Kim, Hack-Lyoung; Kwon, Mi Jung; Oh, Young Ha; Jung, Woon Yong; Moon, Ji-Yong; Hong, Sangmo; Oh, Ki-Wook; Kim, Young Seo.
Afiliação
  • Kim DH; Departments of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
  • Son BK; Department of Internal Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul 01830, Korea.
  • Min KW; Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, Korea.
  • Han SK; Departments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
  • Na JU; Departments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
  • Choi PC; Departments of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
  • Kim HL; Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Korea.
  • Kwon MJ; Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang-si, Gyeonggi-do 14068, Korea.
  • Oh YH; Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, Korea.
  • Jung WY; Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, Korea.
  • Moon JY; Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, Korea.
  • Hong S; Division of Endocrinology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si, Gyeonggi-do 11923, Korea.
  • Oh KW; Department of Neurology, Hanyang University College of Medicine, Seoul 04763, Korea.
  • Kim YS; Department of Neurology, Hanyang University College of Medicine, Seoul 04763, Korea.
J Clin Med ; 9(6)2020 Jun 14.
Article em En | MEDLINE | ID: mdl-32545889
ABSTRACT
Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, Helicobacter pylori (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article