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Topoisomerase 3ß knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
Joo, Yuyoung; Xue, Yutong; Wang, Yue; McDevitt, Ross A; Sah, Nirnath; Bossi, Simone; Su, Shuaikun; Lee, Seung Kyu; Peng, Wei; Xie, Aoji; Zhang, Yongqing; Ding, Yi; Ku, Wai Lim; Ghosh, Soumita; Fishbein, Kenneth; Shen, Weiping; Spencer, Richard; Becker, Kevin; Zhao, Keji; Mattson, Mark P; van Praag, Henriette; Sharov, Alexei; Wang, Weidong.
Afiliação
  • Joo Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Xue Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Wang Y; Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • McDevitt RA; The Comparative Medicine Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Sah N; Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Bossi S; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Su S; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Lee SK; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Peng W; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Xie A; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Zhang Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Ding Y; Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Ku WL; Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Ghosh S; Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Fishbein K; Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Shen W; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Spencer R; Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Becker K; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Zhao K; Laboratory of Epigenome Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Mattson MP; Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • van Praag H; Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
  • Sharov A; Brain Institute and Charles E. Schmidt College of Medicine, Jupiter, FL, 33458, USA.
  • Wang W; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA. SharovAl@grc.nia.nih.gov.
Nat Commun ; 11(1): 3143, 2020 06 19.
Article em En | MEDLINE | ID: mdl-32561719
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Topoisomerases Tipo I / Neurogênese / Disfunção Cognitiva / Transtornos Mentais / Plasticidade Neuronal Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Topoisomerases Tipo I / Neurogênese / Disfunção Cognitiva / Transtornos Mentais / Plasticidade Neuronal Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos