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Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
Mahajan, Mukesh K; Rivera, Elizabeth J; Sun, Helen H; Nagilla, Rakesh; DeMartino, Michael P; Haile, Pamela A; Casillas, Linda N; Marquis, Robert W; Votta, Bartholomew J; Bertin, John; Reilly, Michael A.
Afiliação
  • Mahajan MK; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA. Electronic address: mukesh.k.mahajan@gsk.com.
  • Rivera EJ; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Sun HH; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Nagilla R; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • DeMartino MP; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Haile PA; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Casillas LN; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Marquis RW; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Votta BJ; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Bertin J; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Reilly MA; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, PA, USA.
J Pharm Sci ; 109(10): 3160-3171, 2020 10.
Article em En | MEDLINE | ID: mdl-32565354
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subfamília B de Transportador de Cassetes de Ligação de ATP / Aminoquinolinas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Sci Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subfamília B de Transportador de Cassetes de Ligação de ATP / Aminoquinolinas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Sci Ano de publicação: 2020 Tipo de documento: Article