Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.

Muralidharan, Somsundar V; Nilsson, Lisa M; Lindberg, Mattias F; Nilsson, Jonas A

Muralidharan, Somsundar V; Nilsson, Lisa M; Lindberg, Mattias F; Nilsson, Jonas A.

Afiliação

Muralidharan SV; Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden.
Nilsson LM; Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden.
Lindberg MF; Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden.
Nilsson JA; Department of Surgery, Sahlgrenska Cancer Center, Institute of Clinical Sciences at University of Gothenburg, Gothenburg, Sweden jonas.a.nilsson@surgery.gu.se.

Life Sci Alliance ; 3(8)2020 08.

Article em En | MEDLINE | ID: mdl-32571801

Assuntos

Quinase 1 do Ponto de Checagem/genética; Quinase 1 do Ponto de Checagem/metabolismo; Animais; Linhagem Celular Tumoral; Quinase 1 do Ponto de Checagem/fisiologia; Dano ao DNA/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Proteínas Nucleares/genética; Fosforilação; Inibidores de Proteínas Quinases/farmacologia; Proteínas Quinases/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinase 1 do Ponto de Checagem Limite: Animals Idioma: En Revista: Life Sci Alliance Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia

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