Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis <i>orn</i> Gene Produce Reversible Ethambutol Resistance and Small-Colony-Variant Morphology.

Safi, Hassan; Lingaraju, Subramanya; Ma, Shuyi; Husain, Seema; Hoque, Mainul; Soteropoulos, Patricia; Rustad, Tige; Sherman, David R; Alland, David

Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis orn Gene Produce Reversible Ethambutol Resistance and Small-Colony-Variant Morphology.

Safi, Hassan; Lingaraju, Subramanya; Ma, Shuyi; Husain, Seema; Hoque, Mainul; Soteropoulos, Patricia; Rustad, Tige; Sherman, David R; Alland, David.

Afiliação

Safi H; Center for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Lingaraju S; Center for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Ma S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Husain S; Genomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Hoque M; Genomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Soteropoulos P; Genomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Rustad T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Sherman DR; Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Alland D; Center for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA david.alland@rutgers.edu.

Antimicrob Agents Chemother ; 64(9)2020 08 20.

Article em En | MEDLINE | ID: mdl-32571828

Assuntos

Farmacorresistência Bacteriana; Etambutol; Mutação da Fase de Leitura; Mycobacterium tuberculosis; Antituberculosos/farmacologia; Farmacorresistência Bacteriana/genética; Etambutol/farmacologia; Testes de Sensibilidade Microbiana; Mycobacterium tuberculosis/efeitos dos fármacos; Mycobacterium tuberculosis/genética; Pentosiltransferases/genética

Palavras-chave

cas genes; drug resistance; embC; ethambutol; orn; reversible frameshift; small-colony variant

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutação da Fase de Leitura / Farmacorresistência Bacteriana / Etambutol / Mycobacterium tuberculosis Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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