Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits ß-adrenoceptor-mediated prolongation of cardiac action potential.

Heinick, Alexander; Pluteanu, Florentina; Hermes, Christina; Klemme, Andre; Domnik, Manuel; Husser, Xenia; Gerke, Volker; Schmitz, Wilhelm; Müller, Frank U

Heinick, Alexander; Pluteanu, Florentina; Hermes, Christina; Klemme, Andre; Domnik, Manuel; Husser, Xenia; Gerke, Volker; Schmitz, Wilhelm; Müller, Frank U.

Afiliação

Heinick A; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Pluteanu F; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Hermes C; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Klemme A; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Domnik M; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Husser X; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.
Gerke V; Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.
Schmitz W; Interdisciplinary Clinical Research Center, University of Münster, Münster, Germany.
Müller FU; Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

FASEB J ; 34(8): 10489-10504, 2020 08.

Article em En | MEDLINE | ID: mdl-32579290

Assuntos

Potenciais de Ação/fisiologia; Adenilil Ciclases/metabolismo; Anexina A4/metabolismo; Coração/fisiologia; Miócitos Cardíacos/metabolismo; Receptores Adrenérgicos/metabolismo; Animais; Canais de Cálcio Tipo L/metabolismo; Linhagem Celular; AMP Cíclico/metabolismo; Células HEK293; Humanos; Masculino; Camundongos; Células Musculares/metabolismo

Palavras-chave

FRET; calcium current; cardiomyocytes; co-immunoprecipitation; cyclic AMP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potenciais de Ação / Adenilil Ciclases / Receptores Adrenérgicos / Anexina A4 / Miócitos Cardíacos / Coração Limite: Animals / Humans / Male Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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