Stimulation of hepatic T-kininogen production by interferon.
FEBS Lett
; 229(2): 247-50, 1988 Mar 14.
Article
em En
| MEDLINE
| ID: mdl-3257930
ABSTRACT
T-kininogen is known to be an acute-phase reactant as well as a kininogen in rat plasma. Three kinds of cytokines, interleukin-1, tumor necrosis factor and interferon, were assayed for their abilities to stimulate hepatic production of T-kininogen. Of these cytokines, interferon was able to stimulate hepatic production of T-kininogen, but few effects were observed for interleukin-1 and tumor necrosis factor. In addition, the stimulatory effect of interferon was inhibited by tumor necrosis factor. Our data suggest that interferon is a candidate for the leukocyte-derived factor mediating the acute-phase response of T-kininogen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes
/
Cininogênios
/
Interleucina-1
/
Fator de Necrose Tumoral alfa
/
Fígado
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Japão