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Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe.
Mharakurwa, Sungano; Matsena-Zingoni, Zvifadzo; Mudare, Nobert; Matimba, Charmaine; Gara, Tanatswa Xuxa; Makuwaza, Aramu; Maponga, Gladys; Munyati, Shungu; Gwanzura, Lovemore; Mutambu, Susan L; Mason, Peter; Kobayashi, Tamaki; Midzi, Nicholas; Moss, William J; Ippolito, Matthew M.
Afiliação
  • Mharakurwa S; Department of Health Sciences, Africa University, Mutare, Zimbabwe.
  • Matsena-Zingoni Z; National Institute of Health Research Malaria Section, Harare, Zimbabwe.
  • Mudare N; Department of Health Sciences, Africa University, Mutare, Zimbabwe.
  • Matimba C; Department of Health Sciences, Africa University, Mutare, Zimbabwe.
  • Gara TX; Department of Health Sciences, Africa University, Mutare, Zimbabwe.
  • Makuwaza A; National Institute of Health Research Malaria Section, Harare, Zimbabwe.
  • Maponga G; National Institute of Health Research Malaria Section, Harare, Zimbabwe.
  • Munyati S; Biomedical Research and Training Institute, Harare, Zimbabwe.
  • Gwanzura L; Biomedical Research and Training Institute, Harare, Zimbabwe.
  • Mutambu SL; College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
  • Mason P; Department of Health Sciences, Africa University, Mutare, Zimbabwe.
  • Kobayashi T; Biomedical Research and Training Institute, Harare, Zimbabwe.
  • Midzi N; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Moss WJ; Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Ippolito MM; National Institute of Health Research Malaria Section, Harare, Zimbabwe.
J Infect Dis ; 223(2): 306-309, 2021 02 03.
Article em En | MEDLINE | ID: mdl-32594154
ABSTRACT
Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Resistência a Medicamentos / Cloroquina / Malária Falciparum / Carga Parasitária Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Africa Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Zimbábue
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Resistência a Medicamentos / Cloroquina / Malária Falciparum / Carga Parasitária Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Africa Idioma: En Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Zimbábue