Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.
Hum Brain Mapp
; 43(1): 255-277, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-32596977
ABSTRACT
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Ansiedade
/
Córtex Cerebral
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Metanálise como Assunto
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Interpretação Estatística de Dados
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Estudos Multicêntricos como Assunto
/
Neuroimagem
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos