Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.

Luo, Hong-Cheng; Yi, Ting-Zhuang; Huang, Fu-Gao; Wei, Ying; Luo, Xiao-Peng; Luo, Qi-Sheng

Luo, Hong-Cheng; Yi, Ting-Zhuang; Huang, Fu-Gao; Wei, Ying; Luo, Xiao-Peng; Luo, Qi-Sheng.

Afiliação

Luo HC; Department of Clinical Laboratory, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Yi TZ; Department of Gastroenterology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Huang FG; Department of Ultrasound, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Wei Y; Department of Clinical Laboratory, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Luo XP; Department of Otolaryngology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China yyfyhdy@163.com proluo_qs@163.com.
Luo QS; Department of Neurosurgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China yyfyhdy@163.com proluo_qs@163.com.

J Biol Chem ; 295(41): 14125-14139, 2020 10 09.

Article em En | MEDLINE | ID: mdl-32605923

Assuntos

Autofagia; Isquemia Encefálica/metabolismo; Proteína Adaptadora GRB2/metabolismo; MicroRNAs/metabolismo; Neurônios/metabolismo; RNA Longo não Codificante/metabolismo; Transdução de Sinais; Acidente Vascular Cerebral/metabolismo; Animais; Isquemia Encefálica/genética; Isquemia Encefálica/patologia; Modelos Animais de Doenças; Proteína Adaptadora GRB2/genética; Humanos; Camundongos; Camundongos Mutantes; MicroRNAs/genética; Neurônios/patologia; RNA Longo não Codificante/genética; Acidente Vascular Cerebral/genética; Acidente Vascular Cerebral/patologia

Palavras-chave

Akt/mTOR signaling pathway; autophagy; growth factor receptorbound protein 2 (GRB2); ischemia; ischemic stroke; maternally expressed gene 3; microRNA-378; neurological disease; neurological functional impairment; neuronal autophagy; stroke

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Transdução de Sinais / Isquemia Encefálica / Acidente Vascular Cerebral / MicroRNAs / Proteína Adaptadora GRB2 / RNA Longo não Codificante / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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