Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.

Chen, Daxin; Li, Ke; Festenstein, Sam; Karegli, Julieta; Wilkinson, Hannah; Leonard, Hugh; Wei, Lin-Lin; Ma, Ning; Xia, Min; Tam, Henry; Wang, Jian-An; Xu, Qingbo; McVey, John H; Smith, Richard A G; Dorling, Anthony

Chen, Daxin; Li, Ke; Festenstein, Sam; Karegli, Julieta; Wilkinson, Hannah; Leonard, Hugh; Wei, Lin-Lin; Ma, Ning; Xia, Min; Tam, Henry; Wang, Jian-An; Xu, Qingbo; McVey, John H; Smith, Richard A G; Dorling, Anthony.

Afiliação

Chen D; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Li K; Core Research Laboratory the Second Affiliated Hospital, School of Medicine Jiaotong University Xi'an China.
Festenstein S; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Karegli J; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Wilkinson H; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Leonard H; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Wei LL; Core Research Laboratory the Second Affiliated Hospital, School of Medicine Jiaotong University Xi'an China.
Ma N; Core Research Laboratory the Second Affiliated Hospital, School of Medicine Jiaotong University Xi'an China.
Xia M; Thrombosis Research Institute London United Kingdom.
Tam H; Department of Imaging Imperial College Healthcare NHS Trust Charing Cross Hospital London United Kingdom.
Wang JA; Department of Cardiology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China.
Xu Q; Cardiovascular Division King's College London James Black Centre London United Kingdom.
McVey JH; School of Bioscience & Medicine Faculty of Health and Medical Sciences University of Surrey Guildford United Kingdom.
Smith RAG; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.
Dorling A; Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.

J Am Heart Assoc ; 9(13): e014811, 2020 07 07.

Article em En | MEDLINE | ID: mdl-32611229

Assuntos

Antitrombinas/administração & dosagem; Aorta/efeitos dos fármacos; Doenças da Aorta/prevenção & controle; Aterosclerose/prevenção & controle; Quimiotaxia de Leucócito/efeitos dos fármacos; Monócitos/efeitos dos fármacos; Animais; Aorta/metabolismo; Aorta/patologia; Doenças da Aorta/genética; Doenças da Aorta/metabolismo; Doenças da Aorta/patologia; Aterosclerose/genética; Aterosclerose/metabolismo; Aterosclerose/patologia; Antígeno CD11b/metabolismo; Células Cultivadas; Quimiocinas/metabolismo; Modelos Animais de Doenças; Esquema de Medicação; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Células Endoteliais/patologia; Injeções Intravenosas; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout para ApoE; Monócitos/metabolismo; Fenótipo; Placa Aterosclerótica

Palavras-chave

atherosclerosis; regression; thrombin; thrombin inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Doenças da Aorta / Monócitos / Quimiotaxia de Leucócito / Antitrombinas / Aterosclerose Limite: Animals Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2020 Tipo de documento: Article

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