Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male swiss mice and wistar rats.

Hajhashemi, Valiollah; Ghanadian, Mustafa; Palizaban, Abbasali; Mahnam, Karim; Eshaghi, Hamed; Gheisari, Bahareh; Sadeghi-Aliabadi, Hojjat

Hajhashemi, Valiollah; Ghanadian, Mustafa; Palizaban, Abbasali; Mahnam, Karim; Eshaghi, Hamed; Gheisari, Bahareh; Sadeghi-Aliabadi, Hojjat.

Afiliação

Hajhashemi V; Pharmacology department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: hajhashemi@pharm.mui.ac.ir.
Ghanadian M; Pharmacognosy department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: ghanadi
Palizaban A; Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: palizban@pharm.mui.ac.ir.
Mahnam K; Biology Department, Faculty of Science, Shahrekord University, Shahrekord, Iran. Electronic address: mahnam.karim@sci.sku.ac.ir.
Eshaghi H; Pharmacognosy department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: hamedeshagh@gmail.com.
Gheisari B; Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: b.gheisari@gmail.com.
Sadeghi-Aliabadi H; Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: sadeghi@pharm.mui.ac.ir.

Prostaglandins Other Lipid Mediat ; 150: 106473, 2020 10.

Article em En | MEDLINE | ID: mdl-32634574

Assuntos

Analgésicos/farmacologia; Edema/tratamento farmacológico; Dor/tratamento farmacológico; Fitoterapia/métodos; Extratos Vegetais/farmacologia; Esteroides/farmacologia; Ácido Acético/toxicidade; Animais; Anti-Inflamatórios/farmacologia; Carragenina/farmacologia; Chlorocebus aethiops; Ciclo-Oxigenase 2/química; Inibidores de Ciclo-Oxigenase/farmacologia; Edema/induzido quimicamente; Edema/metabolismo; Edema/patologia; Euphorbia/química; Masculino; Simulação de Acoplamento Molecular; Dor/induzido quimicamente; Dor/metabolismo; Dor/patologia; Ratos; Ratos Wistar; Células Vero

Palavras-chave

Analgesic; Anti-inflammatory; Cycloartane triterpenoids; Cyclooxygenase; Euphorbia spinidens; Molecular docking; cycloart-23-ene-3beta,25-diol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Esteroides / Extratos Vegetais / Edema / Analgésicos / Fitoterapia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Prostaglandins Other Lipid Mediat Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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