Monopolar Spindle 1 Kinase (MPS1/TTK) mRNA Expression is Associated with Earlier Development of Clinical Symptoms, Tumor Aggressiveness and Survival of Glioma Patients.
Biomedicines
; 8(7)2020 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-32635204
ABSTRACT
Inhibition of the protein kinase MPS1, a mitotic spindle-checkpoint regulator, reinforces the effects of multiple therapies against glioblastoma multiforme (GBM) in experimental settings. We analyzed MPS1 mRNA-expression in gliomas WHO grade II, III and in clinical subgroups of GBM. Data were obtained by qPCR analysis of tumor and healthy brain specimens and correlated with the patients' clinical data. MPS1 was overexpressed in all gliomas on an mRNA level (ANOVA, p < 0.01) and correlated with tumor aggressiveness. We explain previously published conflicting results on survival high MPS1 was associated with poorer long term survival when all gliomas were analyzed combined in one group (Cox regression t < 24 months, p = 0.009, Hazard ratio 8.0, 95% CI 1.7-38.4), with poorer survival solely in low-grade gliomas (LogRank p = 0.02, Cox regression p = 0.06, Hazard-Ratio 8.0, 95% CI 0.9-66.7), but not in GBM (LogRank p > 0.05). This might be due to their lower tumor volume at the therapy start. GBM patients with high MPS1 mRNA-expression developed clinical symptoms at an earlier stage. This, however, did not benefit their overall survival, most likely due to the more aggressive tumor growth. Since MPS1 mRNA-expression in gliomas was enhanced with increasing tumor aggressiveness, patients with the worst outcome might benefit best from a treatment directed against MPS1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Biomedicines
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha