Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in patients with Gaucher disease.
Am J Hematol
; 29(4): 189-94, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-3263798
ABSTRACT
Sera from 23 individuals with Gaucher disease (GD) were analyzed for hypergammaglobulinemia and oligoclonal and monoclonal gammopathies. Serum IgG level was elevated in 15/23 (65%) patients, and a diffuse hypergammaglobulinemia was present in 10/23 (43%) patients. An oligoclonal gammopathy was noted in six patients, and a monoclonal gammopathy in two. Lymphocyte subset analysis was also carried out in eight individuals with GD. Four of five individuals showed increased surface Ig-positive lymphocytes, while 7/7 were positive for either increased CD19- and/or CD20-positive lymphocytes. An eighth patient was found to have a B-cell leukemia. Statistical analysis of kappa and lambda histograms were suggestive of a monoclonal excess. However, restriction enzyme analysis of four individuals with GD and increased B cells failed to show any evidence of Ig gene rearrangements. Serum Ig abnormalities and perhaps B-cell lymphocytosis appear to be common in the GD patient population and are not associated with circulating monoclonal lymphocytes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Linfócitos B
/
Doença de Gaucher
/
Hipergamaglobulinemia
/
Linfocitose
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Hematol
Ano de publicação:
1988
Tipo de documento:
Article