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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne, Alyssa N; Zaepfel, Benjamin L; Hayes, Lindsey; Fitchman, Boris; Salzberg, Yuval; Luo, En-Ching; Bowen, Kelly; Trost, Hannah; Aigner, Stefan; Rigo, Frank; Yeo, Gene W; Harel, Amnon; Svendsen, Clive N; Sareen, Dhruv; Rothstein, Jeffrey D.
Afiliação
  • Coyne AN; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Zaepfel BL; Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Hayes L; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Fitchman B; Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
  • Salzberg Y; Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
  • Luo EC; Bioengineering Graduate Program, University of California San Diego College of Engineering, La Jolla, CA 92037, USA.
  • Bowen K; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Trost H; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Aigner S; Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA 92037, USA.
  • Rigo F; Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.
  • Yeo GW; Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA 92037, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92037, USA.
  • Harel A; Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
  • Svendsen CN; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Sareen D; The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Rothstein JD; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jrothstein@jhmi.edu.
Neuron ; 107(6): 1124-1140.e11, 2020 09 23.
Article em En | MEDLINE | ID: mdl-32673563
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Complexo de Proteínas Formadoras de Poros Nucleares / Demência Frontotemporal / Proteína C9orf72 / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Complexo de Proteínas Formadoras de Poros Nucleares / Demência Frontotemporal / Proteína C9orf72 / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos