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Clinical outcomes after percutaneous coronary intervention for early versus late and very late stent thrombosis: a systematic review and meta-analysis.
Yang, Yi-Xing; Liu, Yin; Li, Xiao-Wei; Lu, Peng-Ju; Wang, Jiao; Li, Chang-Ping; Gao, Jing.
Afiliação
  • Yang YX; Tianjin Medical University, No.22 Qi xiang tai Road, Heping District, Tianjin, 300070, People's Republic of China.
  • Liu Y; Department of Cardiology, Tianjin Chest Hospital, No. 261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.
  • Li XW; Department of Cardiology, Tianjin Chest Hospital, No. 261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.
  • Lu PJ; Department of Cardiology, Tianjin Chest Hospital, No. 261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.
  • Wang J; Tianjin Medical University, No.22 Qi xiang tai Road, Heping District, Tianjin, 300070, People's Republic of China.
  • Li CP; Tianjin Medical University, No.22 Qi xiang tai Road, Heping District, Tianjin, 300070, People's Republic of China. lichangping@tmu.edu.cn.
  • Gao J; Cardiovascular Institute, Tianjin Chest Hospital, No.261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China. gaojing2088@163.com.
J Thromb Thrombolysis ; 51(3): 682-692, 2021 Apr.
Article em En | MEDLINE | ID: mdl-32691275
ABSTRACT
Whether the clinical outcomes of stent thrombosis (ST) are different when stratified by time of occurrence remains unclear. The objective of this study was to compare the short- and long-term clinical outcomes after percutaneous coronary intervention (PCI) for early stent thrombosis (EST) versus late stent thrombosis (LST) and very late stent thrombosis (VLST). We enrolled eligible studies searched from the main electronic databases (EMBASE, PubMed, Cochrane). The primary endpoints were in-hospital, 30-day, 1-year and long-term mortality. The secondary endpoints included recurrent stent thrombosis (RST) and target vessel/lesion revascularization (TVR/TLR) during hospitalization, at 30 days, at 1 year and at long-term follow-up. A total of 23 studies with 17,592 patients were included. Compared with mortality rates of the late and very late thrombosis (LST/VLST) group, in-hospital (P = 0.004), 30-day (P < 0.00001), 1-year (P < 0.00001) and long-term mortality rates (P = 0.04) were significantly higher in the EST group. The in-hospital TVR/TLR rates were similar between the EST group and the LST/VLST group. However, a higher trend in TVR/TLR rate at 30 days and a significantly higher TVR/TLR rate at 1 year (P = 0.002) as well as at long-term follow up (P = 0.009) were found in the EST group. EST patients also trended toward higher risk of RST in both short- and long-term follow-up than LST/VLST patients, although differences were not statistically significant. After PCI treatment, patients with EST have worse clinical outcomes in both short- and long-term follow-up than patients with LST/VLST. Further studies are warranted to determine the optimal treatment strategies for EST.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Stents / Reestenose Coronária / Intervenção Coronária Percutânea Tipo de estudo: Diagnostic_studies / Etiology_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Thromb Thrombolysis Assunto da revista: ANGIOLOGIA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Stents / Reestenose Coronária / Intervenção Coronária Percutânea Tipo de estudo: Diagnostic_studies / Etiology_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Thromb Thrombolysis Assunto da revista: ANGIOLOGIA Ano de publicação: 2021 Tipo de documento: Article