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Multicenter prospective study to validate a new transient elastography device for staging liver fibrosis in patients with chronic hepatitis B.
Duan, Wei Jia; Wang, Xiao Zhong; Ma, An Lin; Shang, Jia; Nan, Yue Min; Gao, Zhi Liang; Tang, Hong; Fu, Qing Chun; Xie, Qing; Mao, Qing; Niu, Jun Qi; Han, Tao; Li, Jun; Han, Ying; Cao, Jian Biao; Kong, Yuan Yuan; Shi, Xiao Yan; Lv, Fu Dong; Wang, Tai Ling; Ma, Hong; You, Hong; Ou, Xiao Juan; Jia, Ji Dong.
Afiliação
  • Duan WJ; Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang XZ; Department of Hepatology, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Ma AL; Department of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China.
  • Shang J; Department of Infectious Diseases, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
  • Nan YM; Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
  • Gao ZL; Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
  • Tang H; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
  • Fu QC; Shanghai Liver Diseases Research Center, 85th Hospital, Nanjing Military Command, Shanghai, China.
  • Xie Q; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Mao Q; Department of Infectious Diseases, First Affiliated Hospital of the Army Medical University, Chongqing, China.
  • Niu JQ; Department of Hepatology, First Hospital of Jilin University, Changchun, Jilin Province, China.
  • Han T; Tianjin Key Laboratory of Artificial Cells, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin Third Central Hospital, Tianjin, China.
  • Li J; Department of Infectious Diseases, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
  • Han Y; Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
  • Cao JB; Center of Liver Diseases, General Hospital of Beijing Military Region, Beijing, China.
  • Kong YY; Clinical Epidemiology and Evidence-Based Medical Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Shi XY; Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Lv FD; Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
  • Wang TL; Department of Pathology, China-Japan Friendship Hospital, Beijing, China.
  • Ma H; Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • You H; Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Ou XJ; Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Jia JD; Liver Research Center, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
J Dig Dis ; 21(9): 519-525, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32700794
OBJECTIVES: To validate the operational and diagnostic performances of a new device for transient elastography (TE), FibroTouch, for liver fibrosis in patients with chronic hepatitis B (CHB). METHODS: In this prospective multicenter study, adult patients with CHB and valid liver pathological results were recruited to validate the operational and diagnostic performance of a TE device by FibroTouch for staging liver fibrosis. RESULTS: In total, 517 patients with histologically proven CHB were enrolled. All had achieved at least 10 successful liver stiffness measurements (LSM), resulting in a success rate of 99.1% and reliable evaluations of 95.2%. Altogether 412 patients were included to analyze the diagnostic performance of FibroTouch. The area under the receiver operating characteristic curve for the LSM was 0.846 (95% confidence interval [CI] 0.808-0.880) for fibrosis stage ≥ F1, 0.850 (95% CI 0.811-0.883) for ≥ F2, 0.908 (95% CI 0.876-0.934) for ≥ F3 and 0.874 (95% CI 0.836-0.903) for F4. The diagnostic accuracy of LSM was superior to that of gamma-glutamyl transpeptidase-to-platelet ratio (GPR), aminotransferase-to-platelet ratio index (APRI), or fibrosis index based on 4 factors (FIB-4) index in staging fibrosis F2-F4 (P = 0.007 to < 0.0001). Optimal LSM cut-off values for diagnosing fibrosis stage ≥ F1, ≥ F2, ≥ F3, and F4 were 5.5 kPa, 7.85 kPa, 10.0 kPa, and 12.7 kPa, respectively. CONCLUSION: FibroTouch has a high success rate and good reliability in staging liver fibrosis in patients with CHB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Técnicas de Imagem por Elasticidade Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: J Dig Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite B Crônica / Técnicas de Imagem por Elasticidade Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: J Dig Dis Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China