Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1ß and tumor necrosis factor-&#945; in models of cartilage degradation.

Matta, Csaba; Fellows, Christopher R; Quasnichka, Helen; Williams, Adam; Jeremiasse, Bernadette; Allaway, David; Mobasheri, Ali

Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1ß and tumor necrosis factor-α in models of cartilage degradation.

Matta, Csaba; Fellows, Christopher R; Quasnichka, Helen; Williams, Adam; Jeremiasse, Bernadette; Allaway, David; Mobasheri, Ali.

Afiliação

Matta C; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Fellows CR; Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Quasnichka H; Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Williams A; Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Jeremiasse B; LGC, Cambridgeshire, UK.
Allaway D; Departments of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Mobasheri A; Biomarkers Division, WALTHAM Petcare Science Institute, Waltham-on-the-Wolds, Leicestershire, UK.

J Orthop Res ; 39(5): 1017-1029, 2021 05.

Article em En | MEDLINE | ID: mdl-32725904

Assuntos

Cartilagem Articular/metabolismo; Clusterina/metabolismo; Interleucina-1beta/farmacologia; Fator de Necrose Tumoral alfa/farmacologia; Animais; Condrócitos/metabolismo; Clusterina/genética; Glicosaminoglicanos/metabolismo; Cavalos; Metaloproteinase 13 da Matriz/fisiologia; Metaloproteinase 3 da Matriz/fisiologia; Osteoartrite/metabolismo; Isoformas de Proteínas

Palavras-chave

apolipoprotein J; articular cartilage; biomarker; chondrocyte; clusterin; osteoarthritis (OA); proteomics; secretome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cartilagem Articular / Fator de Necrose Tumoral alfa / Clusterina / Interleucina-1beta Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Orthop Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hungria

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